Role of Cyamopsis Tetragonoloba against Cisplatin Induced Genotoxicity: Analysis of Micronucleus and Chromosome Aberrations in Vivo

The present study aim to examine the cytoprotective effect of herbal drug Cyamopsis tetragonoloba against cisplatin induced Genotoxicity. In the study mice were exposed to cisplatin. MeOH extract of herbal drug C .tetragonoloba (1000-500mg/kg body wt) was administered orally. Bone marrow protection was evaluated by scoring the different type of indusual aberrant, aberrant metaphase and micronuclei formation. Significant reduction in number of aberrant cell and different type of aberration was observed in treated group as compared to cisplatin treated group of animal. The administered of MeOH leaf extract of Cyamopsis tetragonoloba to the animal showed significant reduction in micronucleus induction also. Our findings support the use of Cyamopsis tetragonoloba as protective chemotherapeutic agent, promoting food and its potential for clinical use.